Once-daily budesonide in mild asthma

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Once- vs twice-daily budesonide/formoterol in 6- to 15-year-old patients with stable asthma.

OBJECTIVE To assess efficacy/tolerability of once-daily budesonide/formoterol pressurized metered-dose inhaler (pMDI) versus budesonide pMDI (primary) and twice-daily budesonide/formoterol (secondary) in children/adolescents with asthma stabilized with twice-daily budesonide/formoterol. METHODS This 12-week multicenter, double-blind randomized controlled study (www.clinicaltrials.gov identifi...

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Budesonide once versus twice-daily administration: meta-analysis.

OBJECTIVES The aim of this study was to examine the efficacy of budesonide administered once daily compared to twice daily in asthma. METHODOLOGY Meta-analysis of randomised controlled trials comparing budesonide administered once versus twice a day that presented data on at least one clinical outcome measure was conducted. RESULTS A total of 10 studies, with 1922 children and adults with a...

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Once-daily budesonide MMX in active, mild-to-moderate ulcerative colitis: results from the randomised CORE II study

OBJECTIVE Budesonide MMX is a novel oral formulation of budesonide that uses Multi-Matrix System (MMX) technology to extend release to the colon. This study compared the efficacy of budesonide MMX with placebo in patients with active, mild-to-moderate ulcerative colitis (UC). DESIGN Patients were randomised 1:1:1:1 to receive budesonide MMX 9 mg or 6 mg, or Entocort EC 9 mg (budesonide contro...

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Clinical efficacy of low-dose inhaled budesonide once or twice daily in children with mild asthma not previously treated with steroids.

The aim of the present study was to examine the efficacy of low-dose inhaled budesonide (BUD) administered via Turbuhaler once or twice daily on symptoms, lung function and bronchial hyperreactivity in children with mild asthma. One hundred and sixty-three children (mean age 9.9 yrs, 56 females/107 males) with mild asthma (forced expiratory volume in one second (FEV1) 103% of predicted, morning...

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Once versus twice daily budesonide metered-dose inhaler in children with mild to moderate asthma: effect on symptoms and bronchial responsiveness.

BACKGROUND Simplifying dosing regimens could improve both adherence and asthma-related morbidity. However, there is little information on the effectiveness of once-daily budesonide, administered through a metered dose inhaler (MDI) plus spacer, on asthma symptoms and pulmonary function in asthmatic children. METHODS The aim of this study was to compare the effect of once-daily versus twice-da...

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ژورنال

عنوان ژورنال: Respiratory Medicine

سال: 1998

ISSN: 0954-6111

DOI: 10.1016/s0954-6111(98)90285-2